Endocrine Abstracts

Introduction: Immune checkpoint inhibitors (ICI) are a new drug generation used for advanced neoplasias. They are monoclonal antibodies which enhance the immune system to combat cancer cells. As a result, immunologic tolerance can be altered and autoimmunity triggered. Toxicities associated to ICIs have been named immune-related adverse events (irAE). ‘Time to resolution’ of endocrine irAEs have not been well described as this term has not been defined in clinical tr...

The prevalence of diabetes and glucose intolerance is close to 50% in people older than 65. At the same time, near 50% of people with type 2 diabetes are ≥ 65 years old. But being these figures relevant enough to raise a special consideration about how to manage diabetes in this population, there are other reasons supporting the need of that a special consideration. These other needs are not quantitative but qualitative ones, making older people with diabetes a particula...

Post-surgical hypoparathyroidism occurs as inadvertent removal or irreversible damageparathyroid disease, irreversible or permanent causing decreased action of parathormone leading to hypocalcemia and hypophosphatemia.Clinical Case: A 52-year-old woman referred from our outpatient clinics due to severe hypocalcemia symptomatic; hand and foot cramps, and hyperphosphatemia: albumincorrected calcium. (5.52 mg/dl and phosphate of 6.6 mg/dl). She presents a h...

Background: Chromogranin A (CgA) is the most abundant granin in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). As a tumor marker is moderately sensitive and nonspecific. Meningiomas are benign brain tumors that are usually to recur. Studies have shown in vitro and in vivo that meningiomas, regardless of histology and classification, express somatostatin receptors (SSTRs). GA68-DOTATATE PET is an exciting imaging modality that has shown significant a...

Introduction: Hypocalcemia varies from asymptomatic biochemical abnormality to life-treating disorder, depending on the duration, severity and rapidity of development.Case report: A 77-year-old woman was admitted for study of asymptomatic hypocalcemia discovered in routinely laboratory test. Past medical history, left thyroidectomy by goiter 53 year ago without follow-up. She denied any symptoms. Physical examination. Actinic keratosis in right cheek, sc...

Context: Denosumab, a fully human monoclonal antibody that inactivates receptor activator of nuclear factor k-B ligand (RANKL), is used for osteoporosis treatment because of its potent anti-resorptive properties. Due to its reversible mode of action, bone resorption increases rapidly after its discontinuation and is accompanied by a quick loss of bone mineral density. Spontaneous vertebral fractures at this period have been recognized as secondary to the rebound of bone resorp...

Introduction: Obesity prevalence is growing every year. In most cases, origin is exogenous, a mixture of sedentary and overeating. However, some patients are trend to develop obesity caused by their genetics and other illness.Case report: A 62-year-old women with diabetes type 2, anxiety and osteoporosis was remitted to our center for obesity. She had been obese since childhood, with very low level of activity and snacking trend. On physical examination ...

Introduction: The EDIN study evaluated the clinical course of patients with type 2 diabetes mellitus (T2DM) from the start of the insulin treatment to a minimum of 5 years, within routine clinical practice in Spain.Objective: To describe the characteristics of patients at onset of insulin treatment.Methods: Observational study that consecutively included patients with T2DM, ≥30 years old and treated with insulin for at least ...

INTRODUCTION:Diabetes Mellitus is one of the most important problems which has greater health care impact in Spain. It is concluded from the DCCT study on DM1 and UKPDS in DM2 that control of HbA1c levels is essential to reduce chronic complications. Guidelines suggest maintaining HbA1c levels below 7%.PATIENTS AND METHODS:Design: Epidemiological, longitudinal, prospective and multicenter study in Spain, with two cohorts, DM1 (n=40...

Introduction: Denosumab reduces bone resorption, increases BMD, and reduces fracture risk. Denosumab discontinuation (DD) induces an increase of B-crosslaps above baseline values for two years, and a decrease of BMD values. This rebound effect is associated with spontaneous clinical vertebral fractures (SCVF) in close to 15% of patients considering a follow-up of 2 years without taking another osteoporosis treatment. Prescribing a bisphosphonate or SERMs at DD would prevent th...